NR 507 Week 6 Recorded Disease Process Presentation Peer Review

Sample Answer

2. Analyze pathophysiologic mechanism associated with Addison’s Disease
Mediated destruction

Sanne van Haren, Hannah, Alex & Gijs (2018) indicated as did you that Addison’s Disease Caused by Tuberculosis. Just like Aspergillus Pneumonia, Addison’s disease is difficult to diagnose and treat. Fichna, Żurawek, Bratland, Husebye, Kasperlik-Załuska, Czarnocka & … Nowak. (2015) stated that Interleukin-2 subunit alpha (soluble receptor) reveals and confirms a direct connect between 21OH=directed reactivity and AAD, and 11.2 SNP. Fichna, Żurawek, Bratland, Husebye, Kasperlik-Załuska, Czarnocka & … Nowak. (2015) continued that Addison’s disease (AAD) has a direct connect to T-cell destruction of the adrenal cortex.

So there is lyphocytic infiltration of the adrenal gland, autoantibodies, 21 hydroxylase (21OH). It is also indicated that he etiology remains obscure but genetic and environmental factors can be significant. Your PowerPoint presentation was excellent. I read about genes influencing T-cell fate. Is this true about transcription factors STAT4, GATA3, interleukin-23 (IL23A activates STAT4) and interferon-Gamma production aides in the production of interferon-Gamma by the memory CD4+ cells.

5. Relate research findings to the management of patients with complex pathophysiologic dysfunction of the adrenal cortex and how the hormones are all related.

I can see the difficulty with the treatment in that rifampicin and steroids is part of the treatment, but low dose of steroids can be a problem with any long disorder, especially those who are immunocompromised. In addition, Aspergillus Pneumonia which is a rare opportunistic fungal infection would have a field day and be invasive to this type of individual. Any type of compromised disease would contribute to a host of problems later down the line. As with the disease that I had chosen, systemic considerations should be taken when it comes to signs and symptoms.

For example, similarities exist with both diseases in that weight loss and gastrointestinal symptoms are common signs and symptoms for both. Clara, Joana, Marina, Fábio, Sara, Alexandre & … Teresa (2018) also agree that it is difficult to diagnose Addison’s disease in that this disease is rare and even gave a case about a teenager having multiple visits to the emergency room to which the teenager was treated with hydro cortisone and fludrocortisone and added that Addison’s disease has unspecific symptomatology.

References

• Clara, P., Joana, C., Marina, P., Fábio, B., Sara, L., Alexandre, F., & … Teresa, B. (2018). Addison’s disease – the difficulty of diagnosis. Nascer E Crasser , Vol 27, Iss 1, Pp 39-42 (2018), (1), 39.
• Fichna, M., Żurawek, M., Bratland, E., Husebye, E. S., Kasperlik-Załuska, A., Czarnocka, B., & … Nowak, J. (2015). Interleukin-2 and subunit alpha of its soluble receptor in autoimmune Addison’s disease–an association study and expression analysis. Autoimmunity, 48, 2, 100-107. doi 10.3109/08916934.2014.976628
• Sanne van Haren, N., Hannah, V., Alex, M., & Gijs, L. (2018). Addison’s Disease
  Caused by Tuberculosis Diagnostic and Therapeutic Difficulties. European
  Journal of Case Reports In Internal Medicine (2018), doi 10.12890/2018_000911