NUR 600 Module 2 Assignment Begin Research for Your Drug Projects

Sample Answer

Gabapentin is an antiepileptic medication that is structurally similar to GABA and operates via a distinct mode of action. It interacts with GABA receptors in the central nervous system and may lead to increased production of GABA in neurons (Anderson et al., 2020).

Gabapentin may be useful for people who did not react to antidepressants or mood stabilizers and has few adverse effects. It has effectively managed fast cycling and mixed bipolar episodes in individuals who could not find sufficient relief with carbamazepine and valproate.

Gabapentin seems to have more anxiolytic and antiagitation effects compared to carbamazepine or valproate. It might also be beneficial as a therapy for those with antipsychotic-induced tardive dyskinesia. The typical final dosage of gabapentin ranges from 900 to 2000 mg per day when prescribed for its antidepressant or mood-stabilizing properties.

Evidence indicates that it reduces hyperalgesia after induced pain in human subjects. This work aims to evaluate research papers on the efficacy of gabapentin in pain control.

Bibliography Review

Anderson et al. (2020) conducted a randomized controlled trial that revealed that administering gabapentin before and after posterior spinal fusion for adolescent idiopathic scoliosis resulted in a notable decrease in opioid consumption and visual analog pain scales during the initial two postoperative days.

This finding highlights the efficacy of incorporating gabapentin into a multimodal pain control protocol. The study conducted by Tubog et al. (2023) examined the safety and efficacy of perioperative gabapentin in patients undergoing bariatric surgery.

The study found that gabapentin is a suitable choice for managing postoperative pain in bariatric surgery. In a recent study conducted by Bao et al. (2021), it was found that the combination of gabapentin and opioids was more effective in reducing neuropathic cancer pain compared to using opioids alone.

Davari et al. (2020) performed a comprehensive review and meta-analysis, concluding that both pregabalin and gabapentin are efficacious in managing neuropathic pain linked to spinal cord injury. According to Fan et al. (2021), a comprehensive analysis of randomized controlled trials (RCTs) indicated that gabapentin might be a viable therapy for chronic pelvic pain (CPP) in women.

Additional research is required to investigate the extended advantages and confirm the safety of this treatment in the future since it is currently a preliminary trial.

Table of Evidence

Authors Date Article Name Location Page Number

• Anderson et al. (2020) 05 February 2020 Multimodal pain control in adolescent posterior spinal fusion patients a double-masked, randomized controlled trial to validate the effect of gabapentin on postoperative pain control, opioid use, and patient satisfaction USA 177–185
  
• Tubog et al. (2023) November 19, 2022 Efficacy and Safety of Gabapentin on Postoperative Pain Management After Bariatric Surgery A Systematic Review and Meta-Analysis USA 322-330
  
• Bao et al. (2021) Dec 24, 2020 The efficacy of gabapentin combined with opioids for neuropathic cancer pain a meta-analysis China. 637–644
  Davari et al. (2020) January 1, 2020 Pregabalin and gabapentin in neuropathic pain management after spinal cord injury a systematic review and meta-analysis Korea 3-12
  
• Fan et al. (2021) 04 October 2021 Gabapentin has Longer-Term Efficacy for the Treatment of Chronic Pelvic Pain in Women A Systematic Review and Pilot Meta-analysis. China 1673–1689

Conclusion

The articles above demonstrate the prospective efficacy of gabapentin in the treatment of pain. According to studies, Gabapentin is additionally employed in the treatment of postherpetic neuralgia, a painful condition that develops following shingles.

Gabapentin functions within the brain to alleviate pain and prevent seizures associated with specific nervous system disorders. It is not prescribed for minor injuries, arthritis, or other common pain.

References

• Anderson, D. E., Duletzke, N. T., Pedigo, E., & Halsey, M. F. (2020). Multimodal pain control in adolescent posterior spinal fusion patients a double-masked, randomized controlled trial to validate the effect of gabapentin on postoperative pain control, opioid use, and patient satisfaction. Spine Deformity, 8(2), 177–185. https //doi.org/10.1007/s43390-020-00038-z
  
• Bao, H., Wu, Z., Wang, Q., Wang, J., Zhang, L., Meng, L., & Feng, H. (2021). The efficacy of gabapentin combined with opioids for neuropathic cancer pain a meta-analysis. Translational Cancer Research, 10(2), 637–644. https //doi.org/10.21037/tcr-20-2692
  
• Davari, M., Amani, B., Amani, B., Khanijahani, A., Akbarzadeh, A., & Shabestan, R. (2020). Pregabalin and gabapentin in neuropathic pain management after spinal cord injury a systematic review and meta-analysis. The Korean Journal of Pain, 33(1), 3–12. https //doi.org/10.3344/kjp.2020.33.1.3
  Fan, X., Ren, Y., Xi, F., Wu, H., Ye, X., Jiang, Y., & You, F. (2021). Gabapentin has
• Longer-Term Efficacy for the Treatment of Chronic Pelvic Pain in Women A Systematic Review and Pilot Meta-analysis. Pain and Therapy, 10(2), 1673–1689. https //doi.org/10.1007/s40122-021-00330-4
  
• Tubog, T. D., Harmer, C. M., Bramble, R. S., Bayaua, N. E., & Mijares, M. (2023). Efficacy and Safety of Gabapentin on Postoperative Pain Management After Bariatric Surgery A Systematic Review and Meta-Analysis. Journal of PeriAnesthesia Nursing, 38(2), 322–330. https //doi.org/10.1016/j.jopan.2022.04.017