NUR 600 Module 4 Discussion Treatments for Respiratory Disorders

Sample Answer

Describe the causes of Upper respiratory infections and drug therapy.

Upper respiratory infections (URIs) are commonly caused by viruses, including rhinovirus, influenza, respiratory syncytial (RSV), adenovirus, and coronaviruses such as SARS-CoV-2.

Bacterial pathogens like Streptococcus pneumoniae and Haemophilus influenzae can also contribute to URIs, particularly in cases of bacterial sinusitis or acute bacterial exacerbations of chronic bronchitis. These infections are typically spread through respiratory droplets or contact with contaminated surfaces.

Treatment for URIs is primarily symptomatic, focusing on alleviating discomfort and managing symptoms such as nasal congestion, sore throat, cough, and fever. Over-the-counter medications like analgesics (e.g., acetaminophen, ibuprofen) and decongestants (e.g., pseudoephedrine, phenylephrine) can help relieve symptoms.

Antiviral medicines like oseltamivir may sometimes be prescribed, especially for influenza infections. Antibiotics are generally not recommended for viral URIs but may be considered in cases of bacterial complications or suspected bacterial co-infections (Cheong et al., 2020). Additionally, supportive measures such as hydration, rest, and humidified air can aid in recovery from URIs.

Discuss triggers of asthma and treatment options.

Asthma is a chronic respiratory condition characterized by inflammation and narrowing of the airways, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing.

Various factors can trigger asthma symptoms, including allergens such as pollen, dust mites, pet dander, mold, and cockroach droppings. Environmental irritants like tobacco smoke, air pollution, strong odors, and chemical fumes can also exacerbate asthma.

Respiratory infections, exercise, cold air, changes in weather, and emotional stress are additional triggers. Management of asthma involves both long-term control medications to reduce inflammation and prevent symptoms, as well as quick-relief medications to alleviate acute symptoms.

Long-term control medications include inhaled corticosteroids (e.g., fluticasone, budesonide), long-acting beta-agonists (e.g., salmeterol, formoterol), leukotriene modifiers (e.g., montelukast), and biologic therapies (e.g., omalizumab, mepolizumab) for severe asthma.

Quick-relief medications include short-acting beta-agonists (e.g., albuterol) to relieve symptoms immediately. Additionally, patients may benefit from allergen avoidance strategies, proper inhaler technique, regular lung function monitoring, and an asthma action plan to manage exacerbations effectively.

In severe cases, oral corticosteroids or hospitalization may be necessary (Sharma et al., 2020). Overall, personalized management tailored to each individual’s triggers and severity of asthma is crucial for optimal control of the condition.

Corticosteroids

Corticosteroids are a class of steroid hormones that are naturally produced in the adrenal glands and have potent anti-inflammatory and immunosuppressive properties. They mimic the effects of cortisol, a hormone that regulates metabolism, immune response, and stress.

Corticosteroids are widely used in medicine for their therapeutic effects in managing various inflammatory and immune-mediated conditions. Depending on the condition being treated and the desired therapeutic effect, they can be administered orally, topically, intravenously, or by inhalation.

Inhaled corticosteroids (ICS) are commonly used to manage asthma and chronic obstructive pulmonary disease (COPD) to reduce airway inflammation and prevent exacerbations. Topical corticosteroids effectively treat inflammatory skin conditions such as eczema, psoriasis, and dermatitis.

Systemic corticosteroids, administered orally or intravenously, are used for more severe inflammatory conditions such as rheumatoid arthritis, lupus, inflammatory bowel disease, and certain respiratory conditions like acute exacerbations of asthma or COPD (Zajac, 2021).

However, long-term use of systemic corticosteroids can lead to various adverse effects, including osteoporosis, diabetes, hypertension, weight gain, mood changes, and increased susceptibility to infections.

Therefore, their use is typically limited to short-term or intermittent courses, and patients are often tapered off gradually to minimize withdrawal symptoms and potential adrenal suppression.

Overall, corticosteroids are invaluable in managing various inflammatory and immune-related disorders. Still, their use requires careful consideration of potential risks and benefits and close monitoring for adverse effects.

Describe chronic bronchitis and treatment options.

Chronic bronchitis is a type of chronic obstructive pulmonary disease (COPD) characterized by inflammation and narrowing of the airways, leading to persistent cough with sputum production for at least three months in two consecutive years.

It is often caused by long-term exposure to irritants such as cigarette smoke, air pollution, and occupational dust or chemicals. Chronic bronchitis thickens and narrows the bronchial tubes, leading to difficulty breathing, wheezing, chest tightness, and frequent respiratory infections.

Treatment options for chronic bronchitis aim to alleviate symptoms, improve lung function, and reduce exacerbations. Smoking cessation is paramount and can significantly slow disease progression. Bronchodilators, such as short-acting beta-agonists (e.g., albuterol) and long-acting anticholinergics (e.g., tiotropium), are commonly used to relax the muscles around the airways and improve airflow.

Inhaled corticosteroids may be prescribed to reduce airway inflammation and control symptoms in more severe cases or in combination with bronchodilators. Pulmonary rehabilitation programs, including exercise training, education, and breathing exercises, can help improve exercise tolerance and quality of life (Zhang et al., 2020).

Oxygen therapy may be necessary in advanced stages to maintain adequate oxygen levels. In some cases, antibiotics are prescribed during exacerbations to treat bacterial infections. Vaccination against influenza and pneumonia is recommended to prevent respiratory infections.

Additionally, lifestyle modifications such as avoiding respiratory irritants, maintaining a healthy weight, and staying physically active can help manage chronic bronchitis symptoms and improve overall lung health.

References

• Cheong, D. H., Tan, D. W., Wong, F. W., & Tran, T. (2020). Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases. Pharmacological Research, 158, 104901. https //doi.org/10.1016/j.phrs.2020.104901
  Links to an external site.
  Sharma, A., Tiwari, S., Deb, M. K., & Marty, J. L. (2020). Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) a global pandemic and treatment strategies. International Journal of Antimicrobial Agents, 56(2), 106054. https //doi.org/10.1016/j.ijantimicag.2020.106054
  Links to an external site.
  
• Zajac, D. (2021). Inhalations with thermal waters in respiratory diseases. Journal of Ethnopharmacology, 281, 114505. https //doi.org/10.1016/j.jep.2021.11
  Links to an external site.
  
• Zhang, R., Wang, X., Ni, L., Di, X., Ma, B., Niu, S., … & Reiter, R. J. (2020). COVID-19 Melatonin as a potential adjuvant treatment. Life Sciences, 250, 117583. https //doi.org/10.1016/j.lfs.2020.117583